• Product NameRecombinant Human MSH3
• Brief DescriptionRecombinant Protein
• Purification>85%, as determined by Coomassie blue stained SDS-PAGE
• Immunogen DescriptionFusion protein corresponding to a C terminal 300 amino acids of human mutS homolog 3 (E. coli)
• Target NamemutS homolog 3
• Alternative Names    DUP; FAP4; MRP1
• Accession No. Swissprot:P20585
  Gene Accession:BC130436
• UniprotP20585
• Gene ID4437;
• Calculated MW Predicted molecular weight:59 kDa
• Tag Info His tag C-Terminus, GST tag N-Terminus
• Concentration 1 mg/ml
• Storage -20°C ~ -80°C, Liquid: pH 7.4 PBS. Avoid repeated freeze-thaw cycles.

• Expression system: Escherichia coli

• Fusion protein corresponding to a region derived from 838-1137 amino acids of human MSH3

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.

Note: For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device.

• Gel: 8%SDS-PAGELysate: 10 ug Purified MSH3 Recombinant Protein was analyzed by SDS-PAGE gel and Coomossie Blue Staining

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting