• Product NameRecombinant Human MLH1
• Brief DescriptionRecombinant Protein
• Immunogen DescriptionFusion protein corresponding to C terminal 300 amino acids of human mutL homolog 1
• Target NamemutL homolog 1
• Alternative Names    FCC2; COCA2; HNPCC; hMLH1; HNPCC2
• Accession No. Swissprot:P40692
  Gene Accession:BC006850
• UniprotP40692
• Gene ID4292;
• Storage -20~-80˚C, pH 7.6 PBS

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Note: For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting