• Product NameRecombinant Human SETD2
• Brief DescriptionRecombinant Protein
• Immunogen DescriptionFusion protein corresponding to C terminal 250 amino acids of human SET domain containing 2
• Target NameSET domain containing 2
• Alternative Names    HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP
• Accession No. Swissprot:Q9BYW2
  Gene Accession:BC117162
• UniprotQ9BYW2
• Gene ID29072;
• Storage -20~-80˚C, pH 7.6 PBS

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

Note: For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting