• Product NameDPYD Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen affinity purification.
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total DPYD protein.
• Immunogen Typeprotein
• Immunogen DescriptionFull length fusion protein of human DPYD
• Target NameDPYD
• Alternative Names    DHP; DPD; DHPDHASE
• Accession No. Swiss-Prot#: Q12882
  Gene ID: 1806
• UniprotQ12882
• Gene ID1806;
• Concentration 0.9mg/ml
• Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:25-1:100

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.

• Immunohistochemical analysis of paraffin-embedded Human tonsil tissue using #42963 at dilution 1/25,

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting