• Product NameRecombinant Human DOK4
• Brief DescriptionRecombinant Protein
• Immunogen DescriptionFusion protein corresponding to a region derived from 7-237 amino acids of human docking protein 4
• Target Namedocking protein 4
• Accession No. Swissprot:Q8TEW6
  Gene Accession:BC001540
• UniprotQ8TEW6
• Gene ID55715;
• Storage -20~-80˚C, pH 7.6 PBS

Docking protein 4?is a?protein?that in humans is encoded by the?DOK4?gene. Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.

Note: For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting