• Product NameRecombinant Human BRE
• Brief DescriptionRecombinant Protein
• Immunogen DescriptionFusion protein corresponding to a region derived from 30-147 amino acids of human brain and reproductive organ-expressed (TNFRSF1A modulator)
• Target Namebrain and reproductive organ-expressed (TNFRSF1A modulator)
• Alternative Names    BRCC4; BRCC45
• Accession No. Swissprot:Q9NXR7
  Gene Accession:BC001251
• UniprotQ9NXR7
• Gene ID9577;
• Storage -20~-80˚C, pH 7.6 PBS

Brain and reproductive organ-expressed protein (BRE) is a 415 amino acid protein which binds to the intracellular juxtamembrane domain of the death receptor, tumor necrosis factor receptor 1 (TNF-R1). BRE also binds to the death receptor, FAS. BRE downregulates TNFa-induced activation of NFkB and may play a role in homeostasis or cellular differentiation in cells of epithelial, neural and germ line origins. It inhibits components of the death-inducing signaling complexes that are necessary for activation of the mitochondria, thereby mediating apoptosis. BRE is strongly expressed in the adrenal cortex, medulla, testis and pancreas, and is weakly expressed in the thymus, thyroid, stomach and small intestine.

Note: For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting