• Product NameRecombinant Human MAPKAPK5
• Brief DescriptionRecombinant Protein
• Immunogen DescriptionFusion protein corresponding to a region derived from 305-408 amino acids of human mitogen-activated protein kinase-activated protein kinase 5
• Target Namemitogen-activated protein kinase-activated protein kinase 5
• Alternative Names    MK5; MK-5; PRAK; MAPKAP-K5
• Accession No. Swissprot:Q8IW41
  Gene Accession:BC041049
• UniprotQ8IW41
• Gene ID8550;
• Storage -20~-80˚C, pH 7.6 PBS

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.

Note: For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting