• Product NameRecombinant Human NEDD4L
• Brief DescriptionRecombinant Protein
• Immunogen DescriptionFusion protein corresponding to C terminal 250 amino acids of human neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
• Target Nameneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
• Alternative Names    RSP5; NEDD4-2; NEDD4.2; hNEDD4-2
• Accession No. Swissprot:Q96PU5
  Gene Accession:BC032597
• UniprotQ96PU5
• Gene ID23327;
• Storage -20~-80˚C, pH 7.6 PBS

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension.?

Note: For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting