TBRG1 (transforming growth factor beta regulator 1), also known as TB-5 or NIAM, is a 411 amino acid protein that localizes to the nucleus and contains one FY-rich C-terminal domain and one FY-rich N-terminal domain. Expressed in a variety of tissues, including liver, lung and pancreas, TBRG1 functions as a growth inhibitor that interacts with p14 ARF and MDM2 and is involved in maintaining chromosome stability. Additionally, TBRG1 can activate p53 function, thereby causing cell-cycle arrest and effectively restricting cell proliferation. TBRG1 expression is downregulated in breast, pancreas and kidney tumors, suggesting that TBRG1 participates in tumor suppression. TBRG1 exists as multiple alternatively spliced isoforms and is subject to MDM2-mediated ubiquitination and subsequent proteasomal degradation. Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.
Note: For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device.
