• Product NameRecombinant Human NSMCE2
• Brief DescriptionRecombinant Protein
• Immunogen DescriptionFull length fusion protein
• Target NameNSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
• Alternative Names    NSE2; MMS21; ZMIZ7; C8orf36
• Accession No. Swissprot:Q96MF7
  Gene Accession:BC032797
• UniprotQ96MF7
• Gene ID286053;
• Storage -20~-80˚C, pH 7.6 PBS

NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Note: For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting