• Product NameRecombinant Human ATXN3
• Brief DescriptionRecombinant Protein
• Immunogen DescriptionFusion protein corresponding to a region derived from 112-361 amino acids of human ATXN3
• Target Nameataxin 3
• Alternative Names    AT3; JOS; MJD; ATX3; MJD1; SCA3
• Accession No. Swissprot:P54252
  Gene Accession:BC033711
• UniprotP54252
• Gene ID4287;
• Storage -20~-80˚C, pH 7.6 PBS

Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.?

Note: For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting