PDHK1(Phospho-Thr338) Antibody - SAB

Catalog No.	Package Size	Price	Quantity
11596-1	50ul	$219.00
11596-2	100ul	$319.00

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Description

Product NamePDHK1(Phospho-Thr338) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
ApplicationsWB
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of PDHK1 only when phosphorylated at threonine 338.
Immunogen TypePeptide-KLH
Immunogen DescriptionPeptide sequence around phosphorylation site of threonine 338(Y-S-T(p)-A-P) derived from Human PDHK1.
Target NamePDHK1
ModificationPhospho
Alternative Names PDK1; PDH kinase 1

Accession No. Swiss-Prot: Q15118
NCBI Protein: NP_001265478.1
UniprotQ15118
Gene ID5163;
Target Species Human
Calculated MW 49kd
Concentration 1.0mg/mL
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Background

Published Papers

Inhibition of phosphoglycerate kinase 1 attenuates autoimmune myocarditis by reprogramming CD4+ T cell metabolismInCardiovasc ResOn2023 Jun 13byYang Lu?1?2?3?4,?Ning Zhao et al..PMID: 36726197, , (2023),
PMID: 36726197 Integrative proteogenomic characterization of early esophageal cancerInNat CommunOn 2023 Mar 25byLingling Li , Dongxian Jiang et al..PMID:36966136, , (2023),
PMID: 36966136 Identification of a novel non-ATP-competitive protein kinase inhibitor of PGK1 from marine nature products. In Biochem Pharmacol on 2021 Jan by Yuying Wang, Lulu Sun, et al..PMID:33212041, , (2021),
PMID: 33212041 Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α. In Int J Mol Sci on 2021 Aug 10 by Nives Škorja Milić, Klemen Dolinar, et al..PMID:34445316, , (2021),
PMID: 34445316 View All Published Papers O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth.In Nat Commun on 2020 Jan 7; by Nie H, Ju H, et al..PMID:31911580, , (2020),
PMID: 31911580 Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis: a TCGA pan-cancer analysis. In Cancer Commun (Lond) on 2019 Oct 2 by Shao F, Yang X,et al..PMID:31578148, , (2019),
PMID: 31578148 Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis., , (2016 Mar),
PMID: 26942675 Please let us know if you have published research using #11596 so that we can cite your reference.

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PDHK1(Phospho-Thr338) Antibody #11596

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Application

Species Reactivity