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KHK Isoform A Antibody #21708

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Catalog No. Package Size Price Quantity
50ul $219.00
100ul $319.00
Availability:Yes
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Description
  • Product NameKHK Isoform A Antibody
  • Host SpeciesRabbit
  • ClonalityPolyclonal
  • PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • ApplicationsWB IHC
  • Species ReactivityHu
  • SpecificityThe antibody detects endogenous level of total KHK Isoform A protein.
  • Immunogen TypePeptide-KLH
  • Immunogen DescriptionPeptide sequence around aa.90~95 (T-T-G-S-V) derived from Human KHK Isoform A .
  • Alternative Names    Ketohexokinase; Hepatic fructokinase; KHK
  • Accession No. Swiss-Prot#: P50053-2
    NCBI Gene ID: 3795
    NCBI Protein#: NP_000212.1
  • UniprotP50053
  • Gene ID3795;
  • Calculated MW 33kd
  • Concentration 1.0mg/mL
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C
Application Details
Background

Published Papers

Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. In JHEP Rep on 2020 Nov 20 by Emma L Shepherd, Raquel Saborano, et al..PMID:33490936, , (2021),
PMID: 33490936
IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation. In Cell Signal on 2021 Oct by Jie Zhou, Jie Yang,et al..PMID:34252535, , (2021),
PMID: 34252535
The small intestine shields the liver from fructose-induced steatosis. In Nat Metab on 2020 Jul by Cholsoon Jang, Shogo Wada, et al..PMID: 32694791, , (2020),
PMID: 32694791
Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. In Nat Commun on 2020 Oct 28 by Jiyoung Kim, Jengmin Kang, et al..PMID:33116123, , (2020),
PMID: 33116123
View All Published Papers Increased ketohexokinase-A governs fructose-induced podocyte hypertrophy by IL-6/STAT3 signaling activation, , (2020),
PMID:
Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction. In Cell Metab on 2020 Jul 7 by Ana Andres-Hernando, David J Orlicky, et al..PMID:32502381, , (2020),
PMID: 32502381
Prognostic Impact of Metabolism ReprogrammIng Markers Acetyl-CoA Synthetase 2 Phosphorylation and KetohexokInase-A Expression In Non-Small-Cell Lung CarcInoma. In Front Oncol on 2019 Nov 5 by Yang X, Shao F, et al..PMID:31750240, , (2019),
PMID: 31750240
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.In Nat Cell Biol on 2016 Ma by Xinjian Li , Xu Qian et al..PMID:27088854 , , (2016 May),
PMID: 27088854
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.In Nat Cell Biol on 2016 Ma by Xinjian Li , Xu Qian et al..PMID:27088854 , , (2016),
PMID: 27088854
Please let us know if you have published research using #21708 so that we can cite your reference.

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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep