C12orf10, also known as MYG1, MYG1 is a 376 amino acid nucleo-mitochondrial protein belonging to the UPF0160 (MYG1) family. MYG1 is encoded by a gene that maps to human chromosome 12q13.13 and is ubiquitously expressed in simple as well as complex eukaryotes, with highest levels in testis. Considered to have a metal-dependent protein hydrolase (UPF0160) domain, MYG1 exhibits a mitochondrial targeting signal in the N-terminal region and a Pat7-type nuclear localization signal in the region between amino acids 33-39. Although MYG1 displays differential patterns and levels of expression during embryonic development, expression in normal adult tissues is stable, suggesting MYG1 involvement in early developmental processes and in adult stress/illness conditions. Elevation of MYG1 expression may be also associated with vitiligo susceptibility.
