Wee 2 (Wee1-like protein kinase 2), also known as WEE1B, is a 567 amino acid nuclear protein belonging to the protein kinase superfamily. Expressed in testis, Wee 2 phosphorylates and inhibits Cdc2 and may act as a negative regulator of entry into the G2 to M transition of mitosis. The gene encoding Wee 2 is located on human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
