• Product NameHER4 / ErbB4 Conjugated Antibody
• Host SpeciesMouse
• ClonalityMonoclonal
• Species ReactivityHu, Ms, Rt
• Immunogen DescriptionAmino acids 1280-1308 at C-terminus of ErbB-4 of human origin.
• ConjugatesBiotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation EmissionAF350: 346nm/442nm
  AF405: 401nm/421nm
  AF488: 493nm/519nm
  AF555: 555nm/565nm
  AF594: 591nm/614nm
  AF647: 651nm/667nm
  AF680: 679nm/702nm
  AF750: 749nm/775nm
• Alternative Names    4ICD antibody
  ALS19 antibody
  Avian erythroblastic leukemia viral oncogene homolog 4 antibody
  Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody
  E4ICD antibody
  EC 2.7.10.1 antibody
  Erbb4 antibody
  ERBB4 intracellular domain antibody
  ERBB4_HUMAN antibody
  HER 4 antibody
  HER4 antibody
  human epidermal growth factor receptor 4 antibody
  Mer4 antibody
  MGC138404 antibody
  Oncogene ERBB4 antibody
  p180erbB4 antibody
  Proto-oncogene-like protein c-ErbB-4 antibody
  Receptor protein tyrosine kinase erbB 4 precursor antibody
  Receptor tyrosine protein kinase erbB 4 antibody
  s80HER4 antibody
  Tyrosine kinase type cell surface receptor HER4 antibody
  Tyrosine kinase-type cell surface receptor HER4 antibody
  v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody
  v erb a erythroblastic leukemia viral oncogene homolog 4 antibody
  v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) antibody
  V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 antibody
  Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody
  Verba erythroblastic leukemia viral oncogene homolog 4 antibody
  VERBB2 antibody
  
• Accession No. Swiss-Prot#:Q15303
  
• UniprotQ15303
• Gene ID2066;
• Calculated MW 180kDa
• Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Storage Store at 4˚C in dark for 6 months

• Suggested Dilution:
  AF350 conjugated: most applications: 1: 50 - 1: 250
  AF405 conjugated: most applications: 1: 50 - 1: 250
  AF488 conjugated: most applications: 1: 50 - 1: 250
  AF555 conjugated: most applications: 1: 50 - 1: 250
  AF594 conjugated: most applications: 1: 50 - 1: 250
  AF647 conjugated: most applications: 1: 50 - 1: 250
  AF680 conjugated: most applications: 1: 50 - 1: 250
  AF750 conjugated: most applications: 1: 50 - 1: 250
  Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting