• Product NameM6PR Conjugated Antibody
• Host SpeciesRabbit
• ClonalityMonoclonal
• Species ReactivityHu, Ms, Rt
• Immunogen Descriptionrecombinant protein
• ConjugatesBiotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation EmissionAF350: 346nm/442nm
  AF405: 401nm/421nm
  AF488: 493nm/519nm
  AF555: 555nm/565nm
  AF594: 591nm/614nm
  AF647: 651nm/667nm
  AF680: 679nm/702nm
  AF750: 749nm/775nm
• Alternative Names    300 kDa mannose 6 phosphate receptor antibody
  300 kDa mannose 6-phosphate receptor antibody
  Cation independent mannose 6 phosphate receptor antibody
  Cation-independent mannose-6-phosphate receptor antibody
  CD222 antibody
  CD222 antigen antibody
  CI Man 6 P receptor antibody
  CI Man-6-P receptor antibody
  CI MPR antibody
  CI-M6PR antibody
  CI-MPR antibody
  CIMPR antibody
  IGF 2 receptor antibody
  IGF 2R antibody
  IGF II receptor antibody
  IGF-II receptor antibody
  IGF2 receptor antibody
  Igf2r antibody
  Insulin like growth factor 2 receptor antibody
  Insulin like growth factor II receptor antibody
  Insulin-like growth factor 2 receptor antibody
  Insulin-like growth factor II receptor antibody
  M6P R antibody
  M6P/IGF2 receptor antibody
  M6P/IGF2R antibody
  M6PR antibody
  mannose 6 phosphate receptor antibody
  mannose 6 phosphate receptor, cation independent antibody
  MPR 300 antibody
  MPR300 antibody
  MPRI antibody
  MPRI_HUMAN antibody
  
• Accession No. Swiss-Prot#:P11717
  
• UniprotP11717
• Gene ID3482;
• Calculated MW 274 kDa
• Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Storage Store at 4˚C in dark for 6 months

• Suggested Dilution:
  AF350 conjugated: most applications: 1: 50 - 1: 250
  AF405 conjugated: most applications: 1: 50 - 1: 250
  AF488 conjugated: most applications: 1: 50 - 1: 250
  AF555 conjugated: most applications: 1: 50 - 1: 250
  AF594 conjugated: most applications: 1: 50 - 1: 250
  AF647 conjugated: most applications: 1: 50 - 1: 250
  AF680 conjugated: most applications: 1: 50 - 1: 250
  AF750 conjugated: most applications: 1: 50 - 1: 250
  Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF��1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting