• Product NameRUNX2 Conjugated Antibody
• Host SpeciesRabbit
• ClonalityMonoclonal
• Species ReactivityHu, Ms, Rt
• Immunogen Descriptionrecombinant protein
• ConjugatesBiotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation EmissionAF350: 346nm/442nm
  AF405: 401nm/421nm
  AF488: 493nm/519nm
  AF555: 555nm/565nm
  AF594: 591nm/614nm
  AF647: 651nm/667nm
  AF680: 679nm/702nm
  AF750: 749nm/775nm
• Alternative Names    Acute myeloid leukemia 3 protein antibody
  Alpha subunit 1 antibody
  AML3 antibody
  CBF alpha 1 antibody
  CBF-alpha-1 antibody
  CBFA1 antibody
  CCD antibody
  CCD1 antibody
  Cleidocranial dysplasia 1 antibody
  Core binding factor antibody
  Core binding factor runt domain alpha subunit 1 antibody
  Core binding factor subunit alpha 1 antibody
  Core-binding factor subunit alpha-1 antibody
  MGC120022 antibody
  MGC120023 antibody
  Oncogene AML 3 antibody
  Oncogene AML-3 antibody
  OSF 2 antibody
  OSF-2 antibody
  OSF2 antibody
  Osteoblast specific transcription factor 2 antibody
  Osteoblast-specific transcription factor 2 antibody
  OTTHUMP00000016533 antibody
  PEA2 alpha A antibody
  PEA2-alpha A antibody
  PEA2aA antibody
  PEBP2 alpha A antibody
  PEBP2-alpha A antibody
  PEBP2A1 antibody
  PEBP2A2 antibody
  PEBP2aA antibody
  PEBP2aA1 antibody
  Polyomavirus enhancer binding protein 2 alpha A subunit antibody
  Polyomavirus enhancer-binding protein 2 alpha A subunit antibody
  Runt domain antibody
  Runt related transcription factor 2 antibody
  Runt-related transcription factor 2 antibody
  RUNX2 antibody
  RUNX2_HUMAN antibody
  SL3 3 enhancer factor 1 alpha A subunit antibody
  SL3-3 enhancer factor 1 alpha A subunit antibody
  SL3/AKV core binding factor alpha A subunit antibody
  SL3/AKV core-binding factor alpha A subunit antibody
  
• Accession No. Swiss-Prot#:Q13950
  
• UniprotQ13950
• Gene ID860;
• Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Storage Store at 4˚C in dark for 6 months

• Suggested Dilution:
  AF350 conjugated: most applications: 1: 50 - 1: 250
  AF405 conjugated: most applications: 1: 50 - 1: 250
  AF488 conjugated: most applications: 1: 50 - 1: 250
  AF555 conjugated: most applications: 1: 50 - 1: 250
  AF594 conjugated: most applications: 1: 50 - 1: 250
  AF647 conjugated: most applications: 1: 50 - 1: 250
  AF680 conjugated: most applications: 1: 50 - 1: 250
  AF750 conjugated: most applications: 1: 50 - 1: 250
  Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2αB, CBFA2), RUNX2 (also designated AML-3, PEBP2αA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPαC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting