• Product NameCD74 Conjugated Antibody
• Host SpeciesRabbit
• ClonalityMonoclonal
• Species ReactivityHu
• Immunogen Descriptionrecombinant protein
• ConjugatesBiotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation EmissionAF350: 346nm/442nm
  AF405: 401nm/421nm
  AF488: 493nm/519nm
  AF555: 555nm/565nm
  AF594: 591nm/614nm
  AF647: 651nm/667nm
  AF680: 679nm/702nm
  AF750: 749nm/775nm
• Alternative Names    CD 74 antibody
  CD74 antibody
  CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody
  CD74 antigen antibody
  CD74 molecule antibody
  CD74 molecule, major histocompatibility complex, class II invariant chain antibody
  CLIP antibody
  DHLAG antibody
  Gamma chain of class II antigens antibody
  HG2A_HUMAN antibody
  HLA class II histocompatibility antigen gamma chain antibody
  HLA DR antigens associated invariant chain antibody
  HLA DR gamma antibody
  HLA-DR antigens-associated invariant chain antibody
  HLA-DR-gamma antibody
  HLADG antibody
  HLADR antigens associated invariant chain antibody
  Ia antigen associated invariant chain antibody
  Ia antigen-associated invariant chain antibody
  Ia associated invariant chain antibody
  Ia gamma antibody
  Ii antibody
  Invariant polypeptide of major histocompatibility complex class II antigen associated antibody
  la-gamma antibody
  Major histocompatibility complex class II invariant chain antibody
  MHC HLA DR gamma chain antibody
  MHC HLA-DR gamma chain antibody
  p33 antibody
  p35 antibody
  Protein 41 antibody
  
• Accession No. Swiss-Prot#:P04233
  
• UniprotP04233
• Gene ID972;
• Calculated MW 34 kDa
• Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Storage Store at 4˚C in dark for 6 months

• Suggested Dilution:
  AF350 conjugated: most applications: 1: 50 - 1: 250
  AF405 conjugated: most applications: 1: 50 - 1: 250
  AF488 conjugated: most applications: 1: 50 - 1: 250
  AF555 conjugated: most applications: 1: 50 - 1: 250
  AF594 conjugated: most applications: 1: 50 - 1: 250
  AF647 conjugated: most applications: 1: 50 - 1: 250
  AF680 conjugated: most applications: 1: 50 - 1: 250
  AF750 conjugated: most applications: 1: 50 - 1: 250
  Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

The human histocompatibility leukocyte antigen (HLA) class II-associated invariant chain is composed of at least four polypeptides. One of these polypeptide chains is expressed as a membrane-bound subunit and has been designated CD74. The loading of peptide onto the class II MHC protein (MHC II) appears to be regulated by CD74, which associates with MHC II during its migration to the endosomal compartment, where class II binds pep-tide. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. In fact, CD74 is broadly expressed in normal B lymphocytes, regardless of their histocompatibility leukocyte antigen (HLA) phenotype, while a subset of peripheral T lymphocytes that are MHC II negative do not express CD74.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting