• Product NameFKBP12 Conjugated Antibody
• Host SpeciesRabbit
• ClonalityMonoclonal
• Species ReactivityHu, Ms, Rt
• Immunogen Descriptionrecombinant protein
• ConjugatesBiotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation EmissionAF350: 346nm/442nm
  AF405: 401nm/421nm
  AF488: 493nm/519nm
  AF555: 555nm/565nm
  AF594: 591nm/614nm
  AF647: 651nm/667nm
  AF680: 679nm/702nm
  AF750: 749nm/775nm
• Alternative Names    12 kDa FK506-binding protein antibody
  12 kDa FKBP antibody
  Calstabin 1 antibody
  FK506 binding protein 1 antibody
  FK506 binding protein 12 antibody
  FK506 binding protein 1A (12kD) antibody
  FK506 binding protein 1A 12kDa antibody
  FK506 binding protein 1A antibody
  FK506 binding protein T cell 12 kD antibody
  FK506 binding protein, T cell, 12 kD antibody
  FK506 binding protein12 antibody
  FK506-binding protein 1A antibody
  FKB1A_HUMAN antibody
  FKBP 12 antibody
  FKBP 1A antibody
  FKBP-12 antibody
  FKBP-1A antibody
  FKBP1 antibody
  FKBP12 antibody
  FKBP12 Exip3 antibody
  FKBP12C antibody
  fkbp1a antibody
  Immunophilin FKBP12 antibody
  Peptidyl prolyl cis trans isomerase antibody
  Peptidyl-prolyl cis-trans isomerase FKBP1A antibody
  PKC12 antibody
  PKCI2 antibody
  PPIase antibody
  PPIase FKBP1A antibody
  Protein kinase C inhibitor 2 antibody
  Rotamase antibody
  
• Accession No. Swiss-Prot#:P62942
  
• UniprotP62942
• Gene ID2280;
• Calculated MW 12 kDa
• Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Storage Store at 4˚C in dark for 6 months

• Suggested Dilution:
  AF350 conjugated: most applications: 1: 50 - 1: 250
  AF405 conjugated: most applications: 1: 50 - 1: 250
  AF488 conjugated: most applications: 1: 50 - 1: 250
  AF555 conjugated: most applications: 1: 50 - 1: 250
  AF594 conjugated: most applications: 1: 50 - 1: 250
  AF647 conjugated: most applications: 1: 50 - 1: 250
  AF680 conjugated: most applications: 1: 50 - 1: 250
  AF750 conjugated: most applications: 1: 50 - 1: 250
  Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. FKBP12.6, also known as FK506-binding protein 1B, is a 108 amino acid immunophilin belonging to the FKBP-type PPIase family. Subcellularly localized to the cytoplasm, FKBP12.6 binds to RyR in cardiac muscle sarcoplasmic reticulum and possibly plays a unique physiological role in excitation-contraction coupling in cardiac muscle. FKBP12.6 also catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Ubiquitously expressed, FKBP12.6 is found at highest levels in brain and thymus. FKBP12.6 is expressed as two isoforms produced by alternative splicing.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting