• Product NamePI 3 Kinase p110 delta Conjugated Antibody
• Host SpeciesRabbit
• ClonalityMonoclonal
• Species ReactivityHu, Ms, Rt
• Immunogen DescriptionRecombinant protein
• ConjugatesBiotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation EmissionAF350: 346nm/442nm
  AF405: 401nm/421nm
  AF488: 493nm/519nm
  AF555: 555nm/565nm
  AF594: 591nm/614nm
  AF647: 651nm/667nm
  AF680: 679nm/702nm
  AF750: 749nm/775nm
• Alternative Names    5-bisphosphate 3-kinase 110 kDa catalytic subunit delta antibody
  5-bisphosphate 3-kinase catalytic subunit delta isoform antibody
  APDS antibody
  GRB1 antibody
  IMD14 antibody
  p110d antibody
  p110delta antibody
  p110dp85a antibody
  p85-ALPHA antibody
  Phosphatidylinositol 3 kinase catalytic delta polypeptide antibody
  Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit delta isoform antibody
  Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit delta antibody
  Phosphatidylinositol 4,5 bisphosphate 3 kinase, catalytic subunit delta antibody
  Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit delta isoform antibody
  Phosphatidylinositol-4 antibody
  Phosphoinositide 3 kinase B antibody
  Phosphoinositide 3 kinase C antibody
  Phosphoinositide 3 kinase catalytic delta polypeptide antibody
  Phosphoinositide 3 kinase, catalytic, delta polypeptide variant p37delta antibody
  PI3 kinase p110 subunit delta antibody
  PI3-kinase subunit delta antibody
  PI3K antibody
  PI3K-delta antibody
  PI3Kdelta antibody
  Pik3cd antibody
  PIK3R1 antibody
  PK3CD antibody
  PK3CD_HUMAN antibody
  PtdIns 3 kinase p110 antibody
  PtdIns 3 kinase subunit p110 delta antibody
  PtdIns-3-kinase subunit delta antibody
  PtdIns-3-kinase subunit p110-delta antibody
  
• Accession No. Swiss-Prot#:O00329
  
• UniprotO00329
• Gene ID5293;
• Calculated MW 110 kDa
• Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Storage Store at 4˚C in dark for 6 months

• Suggested Dilution:
  AF350 conjugated: most applications: 1: 50 - 1: 250
  AF405 conjugated: most applications: 1: 50 - 1: 250
  AF488 conjugated: most applications: 1: 50 - 1: 250
  AF555 conjugated: most applications: 1: 50 - 1: 250
  AF594 conjugated: most applications: 1: 50 - 1: 250
  AF647 conjugated: most applications: 1: 50 - 1: 250
  AF680 conjugated: most applications: 1: 50 - 1: 250
  AF750 conjugated: most applications: 1: 50 - 1: 250
  Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 forms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. It has been shown to bind p85α and β, but it apparently does not phosphorylate these subunits. p110δ has the capacity to autophosphorylate and results in the nearly complete inactivation of the lipid kinase activity. Interestingly, p110γ does not interact with the p85 subunits and has been shown to be activated by α and βγ heterotrimeric G proteins. Two p110δ isoforms have been identified and are widely expressed. Isoform 1 is expressed predominantly in leukocytes while isoform 2 is expressed in normal thymus, lung and spleen tissues.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting