• Product NameKMT5A/SETD8/Pr-SET7 Conjugated Antibody
• Host SpeciesRabbit
• ClonalityMonoclonal
• Species ReactivityHu, Ms
• Immunogen DescriptionRecombinant protein
• ConjugatesBiotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation EmissionAF350: 346nm/442nm
  AF405: 401nm/421nm
  AF488: 493nm/519nm
  AF555: 555nm/565nm
  AF594: 591nm/614nm
  AF647: 651nm/667nm
  AF680: 679nm/702nm
  AF750: 749nm/775nm
• Alternative Names    H4 K20 HMTase antibody
  H4 K20 specific histone methyltransferase antibody
  H4-K20-HMTase SETD8 antibody
  Histone H4 K20 methyltransferase antibody
  Histone lysine N methyltransferase H4 lysine 20 specific antibody
  Histone-lysine N-methyltransferase SETD8 antibody
  Lysine N-methyltransferase 5A antibody
  N-lysine methyltransferase SETD8 antibody
  Pr SET 7 antibody
  Pr SET7 antibody
  PR-Set7 antibody
  PR/SET domain containing protein 07 antibody
  PR/SET domain containing protein 8 antibody
  PR/SET domain-containing protein 07 antibody
  PR/SET07 antibody
  PrSET7 antibody
  SET 07 antibody
  SET 8 antibody
  SET domain containing (lysine methyltransferase) 8 antibody
  SET domain containing 8 antibody
  SET domain containing lysine methyltransferase 8 antibody
  SET domain containing protein 8 antibody
  SET domain-containing protein 8 antibody
  SET07 antibody
  SET8 antibody
  SETD 8 antibody
  setd8 antibody
  SETD8_HUMAN antibody
  
• Accession No. Swiss-Prot#:Q9NQR1
  
• UniprotQ9NQR1
• Gene ID387893;
• Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Storage Store at 4˚C in dark for 6 months

• Suggested Dilution:
  AF350 conjugated: most applications: 1: 50 - 1: 250
  AF405 conjugated: most applications: 1: 50 - 1: 250
  AF488 conjugated: most applications: 1: 50 - 1: 250
  AF555 conjugated: most applications: 1: 50 - 1: 250
  AF594 conjugated: most applications: 1: 50 - 1: 250
  AF647 conjugated: most applications: 1: 50 - 1: 250
  AF680 conjugated: most applications: 1: 50 - 1: 250
  AF750 conjugated: most applications: 1: 50 - 1: 250
  Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. All monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions , benef playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contribute to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53 / TP53 at 'Lys-382', leading to repress p53 / TP53-target genes.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting