• Product NameSDHB Conjugated Antibody
• Host SpeciesRabbit
• ClonalityMonoclonal
• Species ReactivityHu, Ms, Rt
• Immunogen DescriptionRecombinant protein
• ConjugatesBiotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation EmissionAF350: 346nm/442nm
  AF405: 401nm/421nm
  AF488: 493nm/519nm
  AF555: 555nm/565nm
  AF594: 591nm/614nm
  AF647: 651nm/667nm
  AF680: 679nm/702nm
  AF750: 749nm/775nm
• Alternative Names    CWS2 antibody
  DHSB_HUMAN antibody
  FLJ92337 antibody Ip antibody
  Iron sulfur subunit antibody
  Iron sulfur subunit of complex II antibody
  Iron-sulfur subunit of complex II antibody
  mitochondrial antibody
  PGL 4 antibody
  PGL4 antibody
  SDH 1 antibody
  SDH antibody
  SDH1 antibody
  SDH2 antibody
  SDH2, homolog of antibody
  SdhB antibody
  SDHIP antibody
  Succinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrial antibody
  Succinate dehydrogenase [ubiquinone] iron sulfur subunit antibody
  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit antibody
  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial antibody
  Succinate Dehydrogenase 1 Iron Sulfur Subunit antibody
  Succinate Dehydrogenase 2, S. cerevisiae, homolog of antibody
  Succinate dehydrogenase complex iron sulfur subunit B antibody
  Succinate dehydrogenase complex subunit B iron sulfur antibody
  Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein antibody
  succinate dehydrogenase complex, subunit B, iron sulfur (Ip) antibody
  Succinate dehydrogenase iron sulfur protein antibody
  
• Accession No. Swiss-Prot#:P21912
  
• UniprotP21912
• Gene ID6390;
• Calculated MW 32 kDa
• Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Storage Store at 4˚C in dark for 6 months

• Suggested Dilution:
  AF350 conjugated: most applications: 1: 50 - 1: 250
  AF405 conjugated: most applications: 1: 50 - 1: 250
  AF488 conjugated: most applications: 1: 50 - 1: 250
  AF555 conjugated: most applications: 1: 50 - 1: 250
  AF594 conjugated: most applications: 1: 50 - 1: 250
  AF647 conjugated: most applications: 1: 50 - 1: 250
  AF680 conjugated: most applications: 1: 50 - 1: 250
  AF750 conjugated: most applications: 1: 50 - 1: 250
  Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations associate with juvenile encephalopathy as well as Leigh syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting