• Product NameSOCS2 Conjugated Antibody
• Host SpeciesRabbit
• ClonalityMonoclonal
• Species ReactivityHu
• Immunogen DescriptionRecombinant protein within human SOCS2 1-150aa.
• ConjugatesBiotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation EmissionAF350: 346nm/442nm
  AF405: 401nm/421nm
  AF488: 493nm/519nm
  AF555: 555nm/565nm
  AF594: 591nm/614nm
  AF647: 651nm/667nm
  AF680: 679nm/702nm
  AF750: 749nm/775nm
• Alternative Names    CIS 2 antibody
  CIS-2 antibody
  CIS2 antibody
  Cish 2 antibody
  Cish2 antibody
  Cytokine inducible SH2 protein 2 antibody
  Cytokine-inducible SH2 protein 2 antibody
  SOCS 2 antibody
  SOCS-2 antibody
  Socs2 antibody
  SOCS2_HUMAN antibody
  SSI 2 antibody
  SSI-2 antibody
  SSI2 antibody
  STAT induced STAT inhibitor 2 antibody
  STAT-induced STAT inhibitor 2 antibody
  STATI 2 antibody
  STATI2 antibody
  Suppressor of cytokine signaling 2 antibody
  
• Accession No. Swiss-Prot#:O14508
  
• UniprotO14508
• Gene ID8835;
• Calculated MW 22 kDa
• Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Storage Store at 4˚C in dark for 6 months

• Suggested Dilution:
  AF350 conjugated: most applications: 1: 50 - 1: 250
  AF405 conjugated: most applications: 1: 50 - 1: 250
  AF488 conjugated: most applications: 1: 50 - 1: 250
  AF555 conjugated: most applications: 1: 50 - 1: 250
  AF594 conjugated: most applications: 1: 50 - 1: 250
  AF647 conjugated: most applications: 1: 50 - 1: 250
  AF680 conjugated: most applications: 1: 50 - 1: 250
  AF750 conjugated: most applications: 1: 50 - 1: 250
  Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting