• Product NameSTUB1 Conjugated Antibody
• Host SpeciesRabbit
• ClonalityMonoclonal
• Species ReactivityHu, Ms, Rt
• Immunogen DescriptionRecombinant protein within human STUB1 aa 1-200.
• ConjugatesBiotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation EmissionAF350: 346nm/442nm
  AF405: 401nm/421nm
  AF488: 493nm/519nm
  AF555: 555nm/565nm
  AF594: 591nm/614nm
  AF647: 651nm/667nm
  AF680: 679nm/702nm
  AF750: 749nm/775nm
• Alternative Names    Antigen NY CO 7 antibody
  Antigen NY-CO-7 antibody
  C terminus of Hsp70-interacting protein antibody
  Carboxy terminus of Hsp70 interacting protein antibody
  Carboxy terminus of Hsp70-interacting protein antibody
  Carboxy terminus of Hsp70p interacting protein antibody
  CHIP antibody
  CHIP_HUMAN antibody
  CLL associated antigen KW 8 antibody
  CLL-associated antigen KW-8 antibody
  E3 ubiquitin protein ligase CHIP antibody
  E3 ubiquitin-protein ligase CHIP antibody
  Heat shock protein A binding protein 2 (c terminal) antibody
  HSPABP2 antibody
  NY CO 7 antibody
  PP1131 antibody
  SDCCAG7 antibody
  Serologically defined colon cancer antigen 7 antibody
  STIP1 homology and U Box containing protein 1 antibody
  STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase antibody
  STIP1 homology and U box-containing protein 1 antibody
  STUB 1 antibody
  STUB1 antibody
  UBOX 1 antibody
  UBOX1 antibody
  
• Accession No. Swiss-Prot#:Q9UNE7
  
• UniprotQ9UNE7
• Gene ID10273;
• Calculated MW 35 kDa
• Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Storage Store at 4˚C in dark for 6 months

• Suggested Dilution:
  AF350 conjugated: most applications: 1: 50 - 1: 250
  AF405 conjugated: most applications: 1: 50 - 1: 250
  AF488 conjugated: most applications: 1: 50 - 1: 250
  AF555 conjugated: most applications: 1: 50 - 1: 250
  AF594 conjugated: most applications: 1: 50 - 1: 250
  AF647 conjugated: most applications: 1: 50 - 1: 250
  AF680 conjugated: most applications: 1: 50 - 1: 250
  AF750 conjugated: most applications: 1: 50 - 1: 250
  Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

CHIP (carboxy terminus of HSP 70-interacting protein), also designated STIP1 homology and U-box containing protein 1, HSPABP2, NY-CO-7, SDCCAG7 and STUB1, is a cytoplasmic E3 ubiquitin ligase that influences protein ubiquitylation. CHIP interacts with Smad1/Smad4 and blocks BMP signaling through the ubiquitin-mediated degradation of Smad proteins. CHIP controls both association of Hsp70/Hsp90 chaperones with ErbB2 and down-regulation of ErbB2 induced by inhibitors of Hsp90. A 1.3-kb transcript is most abundant in striated muscle (heart and skeletal muscle), with lower expression in pancreas and brain.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting