- Product NameTyrosine kinase inhibitor library
- Brief DescriptionAprotein kinaseis akinaseenzymethat modifies other molecules, mostly proteins, by chemically addingphosphategroups to them (phosphorylation) to regulate the majority of cellular pathways, especially those involved insignal transduction. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzymeactivity, cellular location, or association with other proteins.Of the 518 known kinases, the most successful class for drug targeting is the tyrosine kinase family consisting of 90 distinct and diverse members. Abnormal expression of PTK usually leads to cell proliferation disorders, and is closely related to tumor invasion, metastasis and tumor angiogenesis.More recently, PTKs play a pivotal role in inflammatory diseases such as idiopathic pulmonary fibrosis. The Tyrosine Kinase Inhibitors Library by SAB, containing 339 tyrosine kinase inhibitors, can be used for research in tyrosine kinase signaling, and drug screening for related diseases
- Storage Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcodeShipped with blue ice; Stable for One year as powder, 6 months at - 20 ˚ C in DMSO or 12months at -80 ˚ C in DMSO
