- Product NameTGF-beta/Smad Compound Library
- Brief DescriptionMembers of the transforming growth factor-�� (TGF-��) family control growth, differentiation and apoptosis of cells, and have important functions during embryonic development. There are three known isoforms of TGF-�� (TGF-��1, TGF-��2 and TGF-��3) expressed in mammalian tissues. TGF-�� isoforms signal through three surface receptors, known as the TGF-�� type I, type II, and type III receptors (T��RI, T��RII, and T��RIII, respectively) which are expressed on the surface of many cell types such as fibroblasts, lymphocytes, and hemopoietic cells, etc. The binding of TGF-�� and receptorstransduces the signals by phosphorylating carboxy-terminal serine residues of receptor-regulated (R-) Smads. The activated R-Smads form hetero-oligomeric complexes with a common-partner (co-) Smad, that is, Smad4 in vertebrate cells. The complexes translocate into the nucleus where they regulate the expression of target genes. TGF-beta/Smad Compound Library from SAB, a unique collection of 44 TGF-beta/Smad signaling targeted compounds, can be used for research in TGF-beta/Smad signaling and related drug screening (high throughput and high content screening).
- Storage Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcodeShipped with blue ice; Stable for One year as powder, 6 months at - 20 ˚ C in DMSO or 12months at -80 ˚ C in DMSO
