- Product NameWnt&Hedgehog&Notch Compound Library
- Brief DescriptionThe Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology. The Hedgehog (Hh) pathway is a major regulator of many fundamental processes in vertebrate embryonic development including stem cell maintenance, cell differentiation, tissue polarity and cell proliferation.Constitutive activation of the Hh pathway leading to tumorigenesis is seen in basal cell carcinomas and medulloblastoma. A variety of other human cancers, including brain, gastrointestinal, lung, breast and prostate cancers, also demonstrate inappropriate activation of this pathway. Targeting the Hh signaling pathway provides a new and exciting therapeutic option for a broad variety of cancers.TheNotch signaling pathwayis a highlyconservedcell signaling system present in most multicellular organisms. TheNotch signalingcascade is critical forcell proliferation, differentiation, development andhomeostasis. Deregulated Notch signaling is found in various diseases, such asT-cell leukemia, breast cancer,prostate cancer, colorectal cancer andlung canceras well ascentral nervous system(CNS) malignancies, CADASIL, Alagille syndrome, spondylocostal dysostosis, etc. Wnt/Hedgehog/Notch Compound Library from SAB, a unique collection of 74 Wnt/Hedgehog/Notch signaling targeted compounds, can be used for research in Wnt/Hedgehog/Notch signaling and related drug screening (high throughput and high content screening).
- Storage Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcodeShipped with blue ice; Stable for One year as powder, 6 months at - 20 ˚ C in DMSO or 12months at -80 ˚ C in DMSO
