- Product NameMitochondrial Targeting Compound Library
- Brief DescriptionThemitochondrionis a double-membrane-bounddiscrete organellefound in mosteukaryoticorganisms, generating most of the cell's supply ofadenosine triphosphate(ATP) and controlling the cellular basal metabolic rate, called as the cell's powerhouses. In addition to supplying cellular energy, mitochondria are the major source of ROS (reactive oxygen species) that reflect the level of cellular oxidative stress and play an important role in mitochondria ROS signaling such as apoptosis, proliferation, and aging, etc. In addition, the fine modulation of mitochondrial calcium (Ca2+) homeostasis plays a fundamental role in many of the processes involving this organelle. Mitochondrial Ca2+accumulation is a tightly controlled process, in turn regulating functions as diverse asaerobic metabolismand induction ofcell death. Mitochondrial DNA mutations may lead to many mitochondrial metabolic disorders, and are thought to contribute to aging by promoting apoptosis. Mitochondria therefore represent an attractive drug target for metabolic diseases, neurodegeneration, or hyperproliferative diseases (cancer).A number of pre-clinical and clinical data have shown that mitochondria as drug targets have great potential. Small molecule drugs or biologics can act on mitochondria through various pathways including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+modulation, and control of oxidative stressviadecrease or increase of mitochondrial ROS accumulation. Mitochondrial Targeting Compound Library from SAB, a unique collection of 64 compounds targeting mitochondria, can be used for research in mitochondrial medicine and related target study
- Storage Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcodeShipped with blue ice; Stable for One year as powder, 6 months at - 20 ˚ C in DMSO or 12months at -80 ˚ C in DMSO
