A unique collection of 320 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS); Targets include Kinases, GPCR, and ion channels, etc.; Effective tool for drug screening in brain disorders, such as brain tumor, mental disorders, and neurodegenerative diseases, etc.; Safety and effectiveness of the small molecules have been demonstrated through preclinical and clinical research, and some of them are FDA approved; Detailed compound information with structure, target, activity, IC50 value, and biological activity description; Structurally diverse, medicinally active, and cell permeable and CNS penetrant; NMR and HPLC/LCMS validated to ensure high purity and quality