A unique collection of 497 natural products with known anti-cancer activity for high throughput screening (HTS) and high content screening (HCS); Known bioactivity for all compounds: detailed biological and pharmacological information, providing the research foundation and theoretical direction for screening; Clear source: known active natural products selected from animals, plants, or microorganisms with clear species information; Detailed compound information with structure, solubility, targeted signal pathways, action sites, and biological activity description; Cost-effectiveness: expensive natural products with poor drug likeliness are excluded, allowing for more high-quality natural products at a lower cost