• Product NameNBN Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• IsotypeIgG
• PurificationAffinity purification
• ApplicationsWB,IHC
• Species ReactivityHuman,Mouse,Rat
• Immunogen DescriptionRecombinant fusion protein of human NBS1/NBS1/NBN (NP_002476.2).
• Alternative Names    NBN;AT-V1;AT-V2;ATV;NBS;NBS1;P95;nibrin
• Accession No. Uniprot:O60934
  GeneID:4683
• UniprotO60934
• Gene ID4683
• Calculated MW 110kDa
• SDS-PAGE MW 95kDa/70kDa
• Formulation PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Storage Store at -20˚C. Avoid freeze / thaw cycles.

• WB 1:500 - 1:1000
  IHC 1:50 - 1:100

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

• Western blot analysis of extracts of various cell lines, using NBS1/NBS1/NBN antibody.
• Immunohistochemistry of paraffin-embedded human lung cancer using [KO Validated] NBS1/NBS1/NBN Rabbit pAb.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting