• Product NameDR3 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationDEAE purified
• ApplicationsELISA WB
• Species ReactivityHu Ms
• SpecificityDR3 has no cross reaction to other death receptors.
• Immunogen TypePeptide
• Immunogen DescriptionRaised against a peptide corresponding to amino acids 25 to 40 of human DR3 precusor.
• Target NameDR3
• Alternative Names    Wsl-1, Apo-3
• Accession No. Swiss-Prot:Q93038
  Gene ID:8718
• UniprotQ93038
• Gene ID8718;
• Concentration 1mg/ml
• Formulation Supplied in PBS containing 0.02% sodium azide.
• Storage Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Predicted MW: 59 kd

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-κB activation.

• Western blot analysis of DR3 in Jurkat total cell lysate with DR3 antibody at 1:1000 dilution.
• Immunofluorescence of DR3 in Jurkat cells with DR3 antibody at 5 μg/ml.
• Immunocytochemistry of DR3 in Jurkat cells with DR3 antibody at 5 μg/ml.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting