• Product NameDR5 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAffinity chromatography purified via peptide column
• ApplicationsELISA WB ICC
• Species ReactivityHu Ms
• SpecificityAntibody has no cross reaction to DR4.
• Immunogen TypePeptide
• Immunogen DescriptionRaised against a peptide corresponding to amino acids near the carboxy terminus of human DR5 precursor.
• Target NameDR5
• Alternative Names    DR5, TRAIL-R2
• Accession No. Swiss-Prot:O14763
  Gene ID:8795
• UniprotO14763
• Gene ID8795;
• Concentration 1mg/ml
• Formulation Supplied in PBS containing 0.02% sodium azide.
• Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κB.

• Western blot analysis of DR5 in HeLa (H) and K562 (K) cell lysates with DR5 antibody at 2 ug/mL.
• Immunocytochemistry of DR5 in HeLa cells with DR5 antibody at 5 ug/mL.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting