• Product NameTCCR Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAffinity chromatography purified via peptide column
• ApplicationsELISA WB IHC
• Species ReactivityHu
• Immunogen TypePeptide
• Immunogen DescriptionRaised against a synthetic peptide corresponding to amino acids near the carboxy terminus of human TCCR precursor. This sequence is identical to that of mouse TCCR.
• Target NameTCCR
• Alternative Names    Type I T-cell cytokine receptor, IL-27 receptor alpha, IL-27Ra
• Accession No. Swiss-Prot:Q6UWB1
  Gene ID:9466
• UniprotQ6UWB1
• Gene ID9466;
• Concentration 1mg/ml
• Formulation Supplied in PBS containing 0.02% sodium azide.
• Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Predicted MW: 70 kd
  

Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.

• Western blot analysis of TCCR expression in human spleen tissue lysate with TCCR antibody at 1 ug /ml.
• Immunohistochemistry of TCCR in human spleen tissue with TCCR antibody at 5 ug/mL.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting