• Product NameBcl-xL Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationIon exchange chromatography purified
• ApplicationsELISA WB
• Species ReactivityHu
• Immunogen TypePeptide
• Immunogen DescriptionRaised against a peptide corresponding to 14 amino acids near the carboxy terminus of human Bcl-xL.
• Target NameBcl-xL
• Accession No. Swiss-Prot:Q07817
  Gene ID:598
• UniprotQ07817
• Gene ID598;
• Concentration 1mg/ml
• Formulation Supplied in PBS containing 0.02% sodium azide.
• Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.

• Western blot analysis of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 ug/mL.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting