Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st,progenitor to a postmitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st,progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A,BAF53A and PHF10,BAF45A, are exchanged for homologous alternative ACTL6B,BAF53B and DPF1,BAF45B or DPF3,BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal,proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth .
A human homologue of Saccharomyces cerevisiae SNF2,SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.Muchardt C., Yaniv M.EMBO J. 12:4279-4290(1993)
Research Topic:Neuroscience
