• Product NameTWEAK Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationPurified IgG
• ApplicationsELISA WB IHC
• Species ReactivityHu Ms Rt
• Immunogen TypeRecombinant Protein
• Immunogen DescriptionRaised against recombinant human TWEAK.
• Target NameTWEAK
• Alternative Names    TNF-related weak inducer of apoptosis, TNF ligand superfamily member 12
• Accession No. Swiss-Prot:O43508
  Gene ID:407977
• UniprotO43508
• Gene ID407977;8742;
• Concentration 1mg/ml
• Formulation Supplied in PBS containing 0.02% sodium azide.
• Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.

• Western blot analysis of (A) 5 ng, (B) 25 ng and (C) 50 ng of recombinant TWEAK with TWEAK antibody at 1 ug/mL.
• Immunohistochemistry of TWEAK in human brain tissue with TWEAK antibody at 10 ug/mL.
• Immunohistochemistry of TWEAK in mouse brain tissue with TWEAK antibody at 5 μg/mL.
• Western blot analysis of TWEAK in HeLa cell lysate with TWEAK antibody at (A) 1 and (B) 2 μg/mL.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting