Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.Kawakami Y., Eliyahu S., Delgado C.H., Robbins P.F., Rivoltini L., Topalian S.L., Miki T., Rosenberg S.A.Proc. Natl. Acad. Sci. U.S.A.91:3515-3519(1994)
Research Topic:Cancer