JNK1/JNK2/JNK3(Ab-183/185) Antibody - SAB

Catalog No.	Package Size	Price	Quantity
21504-1	50ul	$219.00
21504-2	100ul	$319.00

Catalog No.

Package Size

Price

Quantity

21504-1

50ul

$219.00

21504-2

100ul

$319.00

Product NameJNK1/JNK2/JNK3(Ab-183/185) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of total JNK1/JNK2/JNK3(Ab-183/185) protein.
Immunogen TypePeptide-KLH
Immunogen DescriptionPeptide sequence around aa.182~186 (M-T-P-Y-V) derived from Human JNK1 JNK2 JNK3.
Target NameJNK1 JNK2 JNK3
Alternative Names PRKM8; SAPK1;PRKM9;SAPK1A;JNK3A

Accession No. Swiss-Prot: P45983 P45984 P53779
NCBI Protein: NP_620637.1/NP_002743.3/NP_620448.1
NCBI mRNA:NM_139049.3/NM_002752.4/NM_138982.3
UniprotP45983
Gene ID5599;
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973).

JNK1/JNK2/JNK3(Ab-183/185) Antibody #21504

Published Papers

Customer Reviews and Rankings

My Review

Application

Species Reactivity