• Product NameIntegrin alpha IIb Rabbit mAb
• Host SpeciesRecombinant Rabbit
• ClonalityMonoclonal antibody
• Clone No.S01-1C2
• IsotypeRabbit IgG
• PurificationAffinity Purified
• ApplicationsWB
• Species ReactivityHuman, Rat
• Immunogen DescriptionA synthetic peptide of human CD41
• ConjugatesUnconjugated
• ModificationUnmodification
• Alternative Names    BDPLT2,CD41 antigen, CD41a, gp2b, ITGA2B, platelet fibrinogen receptor alpha
• Accession No. Swiss-Prot:P08514
  GeneID:3674
• UniprotP08514
• Gene ID3674
• Calculated MW Calculated MW: 113 kDa; Observed MW: 137 kDa
• Concentration 0.3 mg/ml
• Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Storage Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.

• WB: 1/2000

Swiss-Prot Acc.P08514.Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

• Western blot detection of CD41 in C6,Hela cell lysates using CD41 Rabbit mAb(1:1000 diluted).Predicted band size:113kDa.Observed band size:137kDa.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting