• Product NameSIGLEC15 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAffinity chromatography purified via peptide column
• ApplicationsELISA WB
• Species ReactivityHu Ms Rt
• SpecificitySIGLEC15 antibody is predicted to not cross-react with other SIGLEC family members.
• Immunogen TypePeptide
• Immunogen DescriptionRaised against a 15 amino acid peptide near the amino terminus of human SIGLEC15.
• Target NameSIGLEC15
• Alternative Names    Sialic acid-binding Ig-like lectin 15, Siglec-15, CD33L3, CD33 antigen-like 3, HST1361
• Accession No. Swiss-Prot:Q6ZMC9
  Gene ID:284266
• UniprotQ6ZMC9
• Gene ID284266;
• Concentration 1mg/ml
• Formulation Supplied in PBS containing 0.02% sodium azide.
• Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.

• Western blot analysis of SIGLEC15 in Rat kidney tissue lysate with SIGLEC15 antibody at (A) 1 and (B) 2 ug/mL
• Western blot analysis of SIGLEC15 in human kidney tissue lysate with SIGLEC15 antibody at (A) 1 and (B) 2 μg/mL.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting