• Product NameIntegrin alpha 2bPolyclonal Antibody FITC Conjugated
• Host SpeciesRabbit
• ClonalityPolyclonal
• IsotypeIgG
• PurificationPurified by Protein A.
• ApplicationsIF
• Species ReactivityHu Ms Rt    
• Immunogen DescriptionKLH conjugated synthetic peptide aa 370-420 1033 derived from mouse Integrin alpha 2b
• ConjugatesFITC
• Excitation Emission494nm 518nm
• Target NameIntegrin alpha 2b CD41
• Alternative Names    CD41; CD41B; GpIIb; AI172977; alphaIIb; Integrin alpha-IIb; GPalpha IIb; Platelet membrane glycoprotein IIb; Itga2b
• Accession No. Swiss-Prot#Q9QUM0
  NCBI Gene ID16399
• UniprotQ9QUM0
• Gene ID16399;
• Cell Localization Extracellular
• Concentration 1mg ml
• Formulation 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
• Storage Shipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.

• IF=1:50-200 

Integrin alpha-IIb beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb beta-3 brings about platelet platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting