• Product NameClaudin-1 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAffinity-chromatography
• ApplicationsWB IHC
• Species ReactivityHu Ms Rt
• SpecificityClaudin 1 antibody detects endogenous levels of total Claudin 1
• Immunogen TypePeptide
• Immunogen DescriptionA synthesized peptide derived from human Claudin 1
• Target NameClaudin-1
• Alternative Names    claudin 1; Claudin-1; CLD1; CLDN1; ILVASC; SEMP1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1
• Accession No. Swiss-Prot#: O95832
• UniprotO95832
• Gene ID9076;
• SDS-PAGE MW 22KD
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
• Storage Store at -20°C/1 year

• WB: 1:500~1:3000
  IHC: 1:50~1:200

 Claudin 1 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Acts as a co- receptor for HCV entry into hepatic cells. Belongs to the claudin family. Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. May interact with HCV E1 and E2 proteins.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting