• Product NameTORC1 Monoclonal Antibody
• Host SpeciesMouse
• ClonalityMonoclonal
• Clone No.4E7-C1-F9-E6
• IsotypeIgM
• ApplicationsWB ICC
• Species ReactivityHu Ms Mk Rt
• SpecificityThis antibody detects endogenous levels of CRTC1 and does not cross-react with related proteins.
• Immunogen TypeRecombinant Protein
• Immunogen DescriptionPurified recombinant human CRTC1 protein fragments expressed in E.coli.
• Target NameTORC1
• Alternative Names    KIAA0616; CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; CRTC1; CRTC1_HUMAN; FLJ14027; KIAA0616; MECT 1; Mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; TORC1;
• Accession No. Uniprot: Q6UUV9

  Gene ID: 23373

• UniprotQ6UUV9
• Gene ID23373;
• SDS-PAGE MW 78kd
• Formulation ascites
• Storage store at -20˚C

• Western blotting: 1:2000 

  Immunocytochemistry: 1:200

 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway,being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene,StAR.Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.May be required for dendritic growth of developing cortical neurons.

• Immunocytochemistry staining of HeLa cells fixed with 4% Paraformaldehyde and using anti-CRTC1 antibody (dilution 1:200).
• Western blot detection of CRTC1 antibody in Hela,mouse brain,SW480,COS7,C6 and 3T3 cell lysates using CRTC1 antibody (1:2000 diluted).Predicted band size:78KDa.Observed band size:78KDa.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting