• Product NameDR5 Monoclonal Antibody
• Host SpeciesMouse
• ClonalityMonoclonal
• Clone No.7F4-F8-G11
• IsotypeIgG1
• PurificationAffinity purified
• ApplicationsWB ICC
• Species ReactivityHu Ms
• SpecificityThis antibody detects endogenous levels of TNFRSF10B and does not cross-react with related proteins.
• Immunogen TypeRecombinant Protein
• Immunogen DescriptionPurified recombinant human TNFRSF10B protein fragments expressed in E.coli.
• Target NameDR5
• Alternative Names    Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L;
• Accession No. Uniprot: O14763

  Gene ID: 8795

• UniprotO14763
• Gene ID8795;
• SDS-PAGE MW 48kd
• Formulation Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
• Storage store at -20˚C

• Western blotting: 1:500-1:2000

  Immunocytochemistry: 1:100

 Receptor for the cytotoxic ligand TNFSF10/TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.Essential for ER stress-induced apoptosis.

• Immunocytochemistry of HeLa cells fixed by Paraformaldehyde and using anti-TNFRSF10B antibody diluted 1:100.
• Western blot detection of TNFRSF10B antibody in Mouse kindey,Mouse brain,HCT116 and Hela cell lysates using TNFRSF10B antibody (1:500-1:2000 diluted).Predicted band size:40/48KDa.Observed band size:40/48KDa.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting