• Product NameVEGFR1 (Phospho-Tyr1048) Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of VEGFR1 only when phosphorylated at tyrosine 1048.
• Immunogen TypePeptide-KLH
• Immunogen DescriptionPeptide sequence around phosphorylation site of tyrosine 1048 (D-I-Y(p)-K-N) derived from Human VEGFR1.
• Target NameVEGFR1
• ModificationPhospho
• Alternative Names    VGFR1; FRT; FLT1; FLT;
• Accession No. Swiss-Prot#: P17948;
  NCBI Gene#: 2321;
  NCBI Protein#: NP_002010.2.
• UniprotP17948
• Gene ID2321;
• SDS-PAGE MW 150kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C/1 year

• Immunohistochemistry: 1:50~1:100

Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Shibuya M., Oncogene 5:519-524(1990).
Kendall R.L., Proc. Natl. Acad. Sci. U.S.A. 90:10705-10709(1993).
The MGC Project Team; Genome Res. 14:2121-2127(2004).

• Immunohistochemical analysis of paraffin-embedded human brain tissue using VEGFR1 (Phospho-Tyr1048) antibody #11759 (left)or the same antibody preincubated with blocking peptide (right).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting