• Product NameTPH2 (Phospho-Ser19) Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
• ApplicationsWB
• Species ReactivityHu Ms Rt
• SpecificityThe antibody detects endogenous levels of TPH2 only when phosphorylated at serine 19.
• Immunogen TypePeptide-KLH
• Immunogen DescriptionPeptide sequence around phosphorylation site of Serine 19(G-F-S(p)-L-D) derived from Human TPH2.
• Target NameTPH2
• ModificationPhospho
• Alternative Names    ADHD7; NTPH; TPH2;
• Accession No. Swiss-Prot#: Q8IWU9;
  NCBI Gene#: 121278;
  NCBI Protein#: NP_775489.2.
• UniprotQ8IWU9
• Gene ID121278;
• SDS-PAGE MW 56kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C/1 year

• Western blotting: 1:500~1:1000

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Walther D.J., Science 299:76-76(2003).
Scherer S.E., Nature 440:346-351(2006).

• Western blot analysis of extracts from HepG2 cells using TPH2 (Phospho-Ser19) Antibody #11828.The lane on the right is treated with the antigen-specific peptide.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting