• Product NameTYR Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntibodies were purified by affinity purification using immunogen.
• ApplicationsWB IHC
• Species ReactivityHuman,Rat,Mouse
• SpecificityThe antibody detects endogenous level of total TYR protein.
• Immunogen TypeRecombinant Protein
• Immunogen DescriptionRecombinant protein of human TYR.
• Target NameTYR
• Alternative Names    CMM8; OCA1A; OCAIA; SHEP3;
• Accession No. Swiss-Prot:P14679
  NCBI Gene ID:7299
• UniprotP14679
• Gene ID7299;
• SDS-PAGE MW 60KD
• Concentration 1.0mg/ml
• Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500 - 1:2000
  Immunohistochemistry: 1:50 - 1:100

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.

• Western blot analysis of HepG2 cell lysate using TYR antibody.
• Immunohistochemical analysis of paraffin-embedded human stomach cancer using TYR antibody at dilution of 1:100 (200x lens).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting