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Histone H2A.X(Ab-139) Antibody #21260

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Catalog No. Package Size Price Quantity
50ul $219.00
100ul $319.00
Availability:Yes
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Description
  • Product NameHistone H2A.X(Ab-139) Antibody
  • Host SpeciesRabbit
  • ClonalityPolyclonal
  • PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • ApplicationsWB IHC IF
  • Species ReactivityHu
  • SpecificityThe antibody detects endogenous level of total Histone H2A.X protein.
  • Immunogen TypePeptide-KLH
  • Immunogen DescriptionPeptide sequence around aa.137~141 (Q-A-S-Q-E) derived from Human Histone H2A.X.
  • Target NameHistone H2A.X
  • Alternative Names    H2A.X; H2AFX; H2a/x; HIST5-2AX;
  • Accession No. Swiss-Prot: P16104
    NCBI Protein: NP_002096.1
  • UniprotP16104
  • Gene ID3014;
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Background

Published Papers

PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity. In Eur Rev Med Pharmacol Sci on 2019 Dec by Li HL, Wang CY, et al..PMID:31841199, , (2019),
PMID: 31841199
Extracts of Zuo Jin Wan, a Traditional Chinese Medicine, Phenocopies 5-HTR1D Antagonist in Attenuating Wnt/β-catenin Signaling in Colorectal Cancer Cells.In BMC Complement Altern Med on 2017 Nov 28 by Jielu Pan, Yangxian Xu,et al..PMID: 29183322, , (2017),
PMID: 29183322
N-Myc Downstream-Regulated Gene 2 (Ndrg2) Is Involved in Ischemia-Hypoxia-Induced Astrocyte Apoptosis: A Novel Target for Stroke Therapy.In Mol Neurobiol on 2017 Jul by Yu-Long Ma, Li-Xia Zhang,et al..PMID:27154863, , (2017),
PMID: 27154863
BASI, A Potent Small Molecular Inhibitor, Inhibits Glioblastoma Progression by Targeting microRNA-mediated β-Catenin Signaling.In CNS Neurosci Ther on 2014 Sep by Zhen-Dong Shi , Xiao-Min Qian et al..PMID: 24810017, , (2014),
PMID: 24810017
View All Published Papers Apoptosis induced by Trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-kB and MAPKs signaling pathways. In Arch Toxicol on 2013 Jul by Yan Qing, Yanfang Liang, et al..PMID: 23423712, , (2013),
PMID: 23423712
Apoptosis induced by Trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-kB and MAPKs signaling pathways. In Arch Toxicol on 2013 Jul by Yan Qing, Yanfang Liang, et al..PMID: 23423712, , (2013),
PMID: 23423712
Up-regulation of NDRG2 through nuclear factor-kappa B is required for Leydig cell apoptosis in both human and murine infertile testes. In Biochim Biophys Acta on 2012 Feb by Teng Li, Jing Hu, et al..PMID:22138128, , (2012),
PMID: 22138128
Nuclear Translocation of β-Catenin Is Essential for Glioma Cell Survival.In J Neuroimmune Pharmacol on 2012 Dec by Zhendong Shi , Xiaomin Qian, et al..PMID:, , (2012),
PMID: 22415719
Anti-inflammatory mechanism of taurine against ischemic stroke is related to down-regulation of PARP and NF-kB. In Amino Acids on 2012 May by Ming Sun, Yumei Zhao, et al..PMID: 21409386 , , (2012),
PMID: 21409386
Up-regulation of NDRG2 through nuclear factor-kappa B is required for Leydig cell apoptosis in both human and murine infertile testes. In Biochim Biophys Acta on 2012 Feb by Teng Li, Jing Hu, et al..PMID:22138128, , (2012),
PMID: 22138128
Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma.In Oral Oncol on 2011 Mar by Li XH, Kikuchi K,et al..PMID:21310648, , (2011),
PMID: 21310648
Cytoplasmic expression of p33ING1b is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma. In Histol Histopathol on 2011 May by Xiao-Han Li, Akira Noguchi, et al..PMID: 21432775, , (2011),
PMID: 21432775
Decreased nuclear expression and increased cytoplasmic expression of ING5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma. In J Cancer Res Clin Oncol on 2010 Oct by Xiaohan Li, Takeshi Nishida, et al..PMID: 20182888, , (2010),
PMID: 20182888
H2AX: Functional Roles and Potential Applications. In Chromosoma on 2009 Dec by Jennifer S Dickey, Christophe E Redon, et al..PMID: 19707781, , (2009),
PMID: 19707781
H2AX: Functional Roles and Potential Applications. In Chromosoma on 2009 Dec by Jennifer S Dickey, Christophe E Redon, et al..PMID: 19707781, , (2009),
PMID: 19707781
Please let us know if you have published research using #21260 so that we can cite your reference.

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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep